V2EX  ›  英汉词典
  •   The specified image does not exist

    Cell-free DNA

    Definition|释义

    细胞游离DNA(cfDNA):存在于血浆、尿液等体液中、不在完整细胞内的DNA片段,通常来自细胞凋亡/坏死或肿瘤细胞释放。常用于无创产前检测(NIPT)癌症“液体活检”、移植监测等。(也常写作 cell free DNA / cfDNA

    Pronunciation|发音(IPA)

    /ˌsɛl ˈfriː ˌdiː.ɛnˈeɪ/

    Examples|例句

    Cell-free DNA can be detected in blood plasma.
    细胞游离DNA可以在血浆中被检测到。

    Researchers measured cell-free DNA to monitor tumor burden over time, enabling less invasive follow-up than repeated biopsies.
    研究人员通过测量细胞游离DNA来长期监测肿瘤负荷,从而实现比反复组织活检更少侵入性的随访。

    Etymology|词源

    cell-free 直译为“无细胞的/脱离细胞的”,用于描述样本中不含完整细胞但含有其释放物的状态;DNAdeoxyribonucleic acid(脱氧核糖核酸)的缩写。医学与遗传学领域在研究血浆中的循环核酸时逐渐固定使用该术语,后来随着无创产前检测与肿瘤检测的发展而广泛流行。

    Related Words|相关词汇

    Literary Works|作品与文献中的使用

    • Lo, Y. M. D. et al. “Presence of fetal DNA in maternal plasma and serum.” The Lancet (1997)
    • Diehl, F. et al. “Circulating mutant DNA to assess tumor dynamics.” Nature Medicine (2008)
    • Wan, J. C. M. et al. “Liquid biopsies come of age: towards implementation of circulating tumour DNA.” Nature Reviews Cancer (2017)
    • 相关专著:Liquid Biopsy: Circulating Tumor Cells, Cell-Free DNA and MicroRNAs(多作者学术书,涵盖cfDNA核心概念与应用)
    About   ·   Help   ·   Advertise   ·   Blog   ·   API   ·   FAQ   ·   Solana   ·   2852 Online   Highest 6679   ·     Select Language
    创意工作者们的社区
    World is powered by solitude
    VERSION: 3.9.8.5 · 31ms · UTC 07:53 · PVG 15:53 · LAX 00:53 · JFK 03:53
    ♥ Do have faith in what you're doing.